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Skeletal Disease Genomics

Evaluation of bone regeneration efficacy of candidate chemical compounds

Evaluation of fracture healing efficacy of candidate chemical compounds

Evaluation of osteoblastic differentiation control of human bone marrow stromal cells (hBMSC) by chemical compounds

Evaluation of tooth formation efficacy of candidate chemical compounds

To regenerate bone defects, our team are taking two approaches. The first one is to potentiate mesenchymal stem cells derived from the bone marrow, adipose tissue and amniotic fluid by manipulating key regulatory genes. Recently identified extracellular matrix protein that can stimulate osteoblast differentiation of bone marrow mesenchymal stem cells is under investigation.

The second approach is to regenerate bone defects using unmanipulated mesenchymal stem cells seeded in three dimensional scaffold for direct clinical applications.

Dental Bone Substitutes

A variety of membrane materials has been developed for guided bone regeneration (GBR) and guided tissue regeneration (GTR) We tested novel biocompatible and degradation-controlled of bone substitutes for the applications to periodontal barrier membranes.

After in vitro degradation tests in bone substisutes were assessed as periodontal barrier membranes for bone regeneration in the calvarial critical size bone defect rabbit. Histological and histomorphometric analyses were carried out after hematoxylin-eosin (H&E) staining of regenerated bones in 4 and 8?weeks.